4. TRANSFER FACTOR RESEARCH

Recently we reported the initial results of a groundbreaking independent study using Transfer Factor and Transfer Factor Plus . Both yielded unprecedented results in a study done by the Institute of Longevity Medicine in California, a laboratory recognized for its research and expertise in measuring the ability of ingredients to significantly boost the immune system.

Transfer Factor and Transfer Factor Plus were tested for their ability to increase Natural Killer Cell (NK) activity. The researchers used peripheral blood mononuclear cells (PBMC) isolated from human volunteers. Test results showed that Transfer Factor boosted NK cell activity 103% above normal immune response without supplementation, more than two times higher than the next highest product. The study also showed that Transfer Factor Plus increased the NK cell activity 248% above normal immune response without supplementation, or about five times higher than any of the other previously tested products.

Natural Killer Cells are an important part of our body's immune system. They seek and destroy harmful cells through direct contact. Natural Killer Cells are especially important in strengthening and supporting the immune system.

David Lisonbee, CEO of 4Life Research, in response to this research said, "These recent findings support and substantiate the reports from thousands of distributors who use Transfer Factor and Transfer Factor Plus. The study also supports many other clinical experiences and studies we are familiar with. We are very pleased with the study results, they come as no surprise to us."



A Noni (Morinda citrifolia),
B Aloe Vera Concentrate (acemannan)
C Endocrine System Formula,
D Phytonutrient Formula with Garlic,
E Bovine Colostrum,
F Cordyceps Formula,
G Shiitake Mushroom,
H Echinacea,
I Plant Polysaccharide Formula,
J IP6, (Highest of group previously tested)
K 4Life Transfer Factor ,
L 4Life Transfer Factor Plus

Independent Bio-Assay Overview
December 11, 1998

Salt Lake City, UT - 4Life Research, a Provo, Utah research and development company released its latest assaying and testing for its new 4Life Transfer Factor product.

Transfer factor is a scientifically recognized delivery system for transferring immune system advantages from one species to another. In the patented process licensed to 4Life, immune factors are generated in cows and then "transferred" as a nutritional supplement to humans. Products manufactured incorporating the process are anticipated by industry experts to be the "next wave" of nutritional supplementation, operating in the newly defined area of "structure/function" claims. Dr. William Hennen, who is one of the world authorities on transfer factor, says of the science and technology: "Transfer factor is a material that has the ability to modulate the immune system. 4Life Transfer Factor contains both materials that help the immune system respond more effectively and materials to make sure the immune system is not over-responding."

4Life's founder and president, David Lisonbee said, "4Life has an agreement with the patent inventors to market transfer factor. United States Patent No. 4,816,563, issued on March 28, 1989, is licensed to 4Life. This patent describes the proprietary process used by 4Life to create its unique Transfer Factor.

The only patent 4Life is aware of which identifies transfer factor in colostrum, the process for obtaining transfer factor from colostrum and whey, and the patented method "to further concentrate and/or purify transfer factor" from colostrum, is the one licensed to 4Life. It is United States Patent No. 4,816,563.

Laboratory Testing of 4Life's Transfer Factor
According to William Hennen, Ph.D., Vice President of Research and Development at 4Life, "Each and every batch of Transfer Factor is tested by an independent laboratory with established, documented credentials in assessing for transfer factor activity. Very few laboratories have the experience or credentials to assay for TF activity. We go to great lengths to assure the quality of transfer factor in our product. This is the reason our distributors are consistently having such great success with Transfer Factor . From infants to the elderly, reports keep coming in every day with results that have matched or exceeded our every expectation. Transfer factor has nearly 50 years of research and over 3,000 clinical studies and scientific papers proving its existence and effectiveness. Our licensed patent proved for the first time that transfer factor exists in colostrum and that it can be successfully extracted and assayed."

Independent Laboratories Show Transfer Factor Activity in 4Life's Transfer Factor
Independent laboratory tests clearly indicate that 4Life's Transfer Factor shows significant transfer factor activity equal to the effectiveness of the standard vaccine.
The biological and chemical testing laboratory, BioLogics Inc. states the following regarding 4Life's Transfer Factor :

"BioLogics Inc. has completed testing the preparations of bovine colostrum you sent for evaluation for TF (transfer factor) activity. Each preparation was evaluated for TF activity using a mouse foot- pad assay which measures delayed-type hypersensitivity (DTH). The results are shown below. A preparation was considered active if it induced significant DTH (p<0.005>P>0.001 YES (P<0.01)>P>0.10 NO (P>0.10) Failed
4Life Transfer Factor
Patented extract of colostrum 0.01>P>0.001 YES (P<0.01)>P>0.001 YES (P<0.01)>P>0.10 NO (P>0.10) Failed
4Life Transfer Factor
Patented extract of colostrum 0.01>P>0.001 YES (P<0.01) Very Active


"Further, it is critical to understand that a proper transfer factor assay includes both a zero-point standard and a high-end standard (to set the span of the scale.) The zero-point standard accounts for the nutritional value of the transfer factor preparation and is represented by the fractionated colostrum listed in the second row above. A vaccinated control is the GOLD STANDARD for establishing the high-end of the immunological scale as represented in the first row.
As was clearly shown, 4Life's Transfer Factor was not only measurably more potent than the normal colostrum of the second row, it was equal to the vaccine standard in causing a strong immune response," stated Dr. Hennen.

Top Transfer Factor Researcher Tests 4Life's Transfer Factor
One of the world's leading TF researchers has also tested 4Life's Transfer Factor using a mouse foot-pad assay.
"Three different colostrum extracts were tested, one of which was 4Life's Transfer Factor . 4Life's Transfer Factor tested highest in TF activity of any of the samples tested."



Retrospective Study
by Dr. David Markowitz


As a means of introducing myself, let me share some of my background with you. I have been a practicing General Pediatrician for the past 18 years, the last ten of which I have been in Kennebunk Maine. I trained at the University of Connecticut for Medical School, Internship and Residency in Pediatrics, and a Fellowship in Pediatric Hematology/Oncology (childhood cancer). I have encouraged our patient population to use natural products to boost their inherent health and help prevent disease for the past ten years. Most of my knowledge about this natural approach is self-taught, because little if any nutrition or prevention is taught in traditional medical school. Thankfully, this is changing. You are forcing this change because you now demand of your practitioners to learn more as you ask detailed questions of them. (Good for you!)

I joined 4Life Research in the summer of 1998 because of my commitment to a natural approach to Health and Wellness and because of my belief in Transfer Factor and in the people who lead this Company. This decision has changed my life and the lives of many patients and patient famiies! OUR EARLY PRACTICE EXPERIENCE: We have introduced Transfer Factor to over 150 families with now over 200 persons using Transfer Factor on a daily basis. I now review the charts of these children on an every two month basis. The facts back up our general impression of greater health and less illness in these children. Effective 2/1/99, we have seen 80% less illness reported to us in these kids and 85% less use of antibiotics, when we compare their histories of last sick season to this year. We will soon match Transfer Factor users to like-aged children not using Transfer Factor and will report those findings when available. Most of our victories in Health have been "quiet", in that we seem to see these transfer factor kids so rarely. Some of our experience has been absolutely remarkable. To share just one with you, we have a 12 year old girl with Spinal Muscular Atrophy (one of the Jerry Lewis muscular dystrophies), who in previous years has had dozens of serious respiratory diseases requiring repeated use of antibiotics to just keep her alive. She this year has used Transfer Factor daily for six months and has required antibiotics just once and has never had a serious chest or respiratory infection. Transfer Factor has changed her life! I will share more with you over time.

Addendum 3/13/99: We now have over 210 patients using Transfer Factor with continued success. One mother who has Hodgkin's Lymphoma now status post chemo and radiation therapy takes Transfer Factor daily: in three months, she has been infection-free with "daily improvement in her health and feeling of well-being" (her words). Her prior history was one with constant respiratory infections due to her severely depressed immune system. Just another quiet victory for Transfer Factor and 4Life Research. Another interesting observation from our patients: if a child stops taking Transfer Factor , we have noticed that within 3-6 weeks, this child is in our office with some infection or another. We know that Transfer Factor has a half-life of about 3 weeks. This observation then fits what we know from the biologic studies. Parents then reorder the Transfer Factor to "never run out". Transfer Factor is indeed a science-based product, just as all the 4Life Research products are.

Addendum 3/18/99: Another "little success story from Maine": We have a beautiful young boy who has suffered with a rare condition called cellular interstitual pneumonitis with multiple episodes of respiratory diseases over the years. After 4 months of Transfer Factor on a daily basis, he has had but one mild upper respiratory infection and no use of antibiotics during one of the worst viral respiratory and flu seasons in southern Maine in a decade. Side effects of Transfer Factor : NONE. Need I say more! We start our age-matched study of our Transfer Factor kids in late April 1999. I will update as data is available.

I am delighted to share with you my appointment to 4 Life Research Medical Advisory Board. We hope to encourage the development of an entire line of children's Health and Wellness products.

Addendum 4/20/99: Just returned from a Wonderful First Leadership Conference. Thank all of you for your kind words and support of children. It is truly heartening to see and feel the commitment. An update as to our kids here locally: review of records show a 79% reduction in reported illness and an 82% reduction in the use of antibiotics. Still truly amazing results with thusfar no untoward side effects. One additional single victory: an 8 year old with Juvenile Rheumatoid Arthritis now on Transfer Factor and FibroAMJ and in FULL remission for 8 weeks and on no traditional allopathic meds. The quality of this child's life has dramatically improved.

Addendum 4/27/99: A hint of what is coming! During the Leadership Conference, Dr. William Hennen announced the introduction of a second generation Transfer Factor product, called Transfer Factor Plus. This will not replace Transfer Factor, just augment it's usefulness, by boosting additional components of the immune system in different and possibly more effective ways, particularly in the body's constant battle against bacterial disease and malignancy. This product, just as all the 4LR products, will cure nothing: it rather boosts the body's ability to handle a multitude of health challenges, in this case, via the immune system. Dr. Hennen will share many more details about T-F Plus in the near future on our website. And 4LR has already starting working on the third and fourth generations of Transfer Factor , each with a promise of greater Health and Wellness!

Addendum 5/5/99: Some wonderful news to share with you. We now have two brothers who carry the diagnosis of Autism, both on Transfer Factor for 4 months. Mother reports a dramatic increase in communication skills and much improved interactions with people and decreased "flapping" behavior. She is quietly delighted (holding her breath!). Our age-matched review will start in late 5/99. Will add details as they become available.

Addendum 5/8/99: More great news, this time using Transfer Factor in an 8 year old with recurrent leukemia on harsh chemotherapy. Since using Transfer Factor the last three months, this young man has has NO untoward side-effects due to chemo and has had no fever episodes requiring admission to hospital and antibiotic use. And he is doing very well with his leukemia as well. Soon he will start on the new T Factors Plus product (June 1999). Will update as progress becomes available.

Addendum 5/15/99: First some quick news: I will be presenting our Transfer Factor experience in Philadelphia this coming Saturday, 5/22/99. Hope to see you there. Additional practice news with some early experience with T-Factors +: As a Medical Advisory Board member, I had three bottles of pre-release Transfer Factor Plus available to me. We used it in a 6 year old with an antibiotic resistant sinusitis (28 day treatment). Within 36 hours of Transfer Factor Plus use, he was TOTALLY CLEAR of congestion, fever, and the thick purulent green nasal discharge had cleared. A 49 year old father of a patient with an undiagnosed mass in his throat and neck: he refused to see his allopathic MD out of fear but wanted to try something "natural". I encouraged him to see his doctor and offered him some Transfer Factor Plus. After three weeks of use, it has been reduced 80% in size. He is delighted and now has promised to see his doctor for a follow-up. We also have two adults with metastatic malignancy who have started on the product with thusfar no feedback. Will keep all informed of their progress. Total patient load now using Transfer Factor is over 250. Have also started the tedious task of an age and sex-matched review of our Transfer Factor experience this past sick season. Will have results within the next three months.

Addendum 5/23/99: Early results from the first of four months of study re: age-matching. We have now compared 25% of our 125 kids on Transfer Factor to like aged and sexed children in the practice who sis not use Transfer Factor : Although preliminary in nature, we see a 62% reduction in reported illness and an 85% reduction in reported antibiotic use in those children who used Transfer Factor daily. I remind all that this is but 25% of the data, so stay tuned for the remainder over the next 2-3 months. Our first two Transfer Factor Plus reports: a 6 year old boy with a 28 day history of antibiotic-resistant sinusitis responded in less than 36 hours of immune boosting with Transfer Factor Plus (one cap twice daily). He was symptom-free at 36 hours! Another experience for the books: a 49 year old with an undiagnosed mass (4-5 cm) in his neck and throat of 4 months duration and growth, who refused to see his allopathic MD out of fear. There is no demonstrable mass in this neck/throat after 23 days of immune-boosting with 2 caps of Transfer Factor Plus three times daily. He was strongly encouraged to see his MD for diagnosis and follow-up. Thusfar he has refused to do so, but we are still working on him. He continues to promise that he will follow up with his physician. More experience with Transfer Factor Plus to follow. Addendum 6/5/99: Our 49 year old father of one of our patients did see his MD and found to have normal exam. Chest X-ray was clear and now remains asymptomatic for 6 weeks on Transfer Factor Plus . We have now compared 45% of our Transfer Factor users to age- and sex-matched patients in the practice for the last 9 months. Still astouding results with 68% less reported illness and 84% less use of antibiotics. We now have used T-Factors Plus in 7 people, 5 with bacterial disease (4 sinusitis and 1 impetigo) and 2 with apparent malignant disease, thusfar with all positive experiences. Total Transfer Factor users in the practice number 250 children and many of their parents. We now encourage all of our Transfer Factor families and new users to stay on Transfer Factor as their immune boosting base and use T-Factors Plus as an additional supplement at times of "stress". Now Transfer Factor, T-Factors Plus, and BioVits fill our patient families' "Health and Wellness" cabinet (notice, not a "medicine" cabinet). More later...

Addendum 7/2/99: And now on to our age/sex-matched study. . . I have now completed a retrospective study comparing kids in the Practice who have used Transfer Factor consistently for six or more months to same sexed and aged children in the Practice who did not use Transfer Factor during the same period. Our computers matched the ages and sexes of the children. All records were reviewed including those of our office, those of cross-covering MD's and the ER and data were compared. The results are indeed remarkable! We found 74% less reported illness and 84% less reported use of antibiotics in the consistent Transfer Factor users when compared to non-Transfer Factor users. 125 Transfer Factor users were reviewed with 87 kids using Transfer Factor consistently for six months or more, aged 8 months to 9 years. We are delighted with these results! We will be preparing manuscripts for submission to various medical journals and hopefully, allowing us to share our results with the more traditional allopathic medical world. A T- Factors Plus experience to report: a 37 year old father of 4 children, diagnosed with advanced Hepatitis C, complicated by gastro-esophageal reflux, chronic constipation, severe fatigue, and sleeplessness. After only 2-3 weeks of Transfer Factor Plus at 2 caps three times daily, this man reports improved liver function testing (by documented lab testing), NO reflux, much improved bowel function (he has stopped all meds!), and now much improved energy and sleep (6-8 hours nightly). We know that Hep C is an "envelope virus" and with improved immune and complement function with Transfer Factor Plus boosting, it would appear that he is now able to better handle this chronic viral infection NATURALLY! Will update you on his condition as time passes. Our 49 year old with the unidentified neck mass continues to be symptom-free and feeling well. More later...

Addendum 7/13/99: People say that Summer is "slow" for networkers. I remind all of you that every day of every month of every season is the right and only time to share these products. And if you think about it, those with Fibro or Chronic Fatigue need us now more than ever. They deserve to feel good during these warm summer months. How about 1-2 months of immune-boosting before the cold weather hits in the Fall. We would all be healthier this coming sick season with 2 months of Transfer Factor or Transfer Factor Plus on board. Traveling this Summer for vacation What an extra-ordinary opportunity to share our Mission and Products with people in other areas. Our goal is to get the word out there that people can live Healthier lives. Summer is "slow" if only you choose it to be that way! Now GO FORTH and share our Vision for Health and Wellness. I look forward to meeting many of you in the San Francisco area at the end of the month! Now fill your Health and Wellness Cabinet with Transfer Factor , Transfer Factor Plus , and the rest of 4LR products and share them with the rest of the World!
I bid you Peace. Dr. David